Today is HIV Vaccine Awareness Day. As those around me have probably picked up on, making an HIV vaccine has become one of my causes. In the quickest vaccine development ever, we made a COVID vaccine in a number of months, but it’s been almost 40 years since AIDS came to light, you say… Why haven’t we developed an effective HIV vaccine when COVID’s was made so quickly? For one, COVID has significantly less mutations.…
Pandemics were on global leaders’ agendas before 2020, but since no global catastrophe happened since 1918, most did not prioritize these concerns. I hope that will not happen as much going forward. Preventative work has gained a new life. Bill Gates, co-founder of both Microsoft and the philanthropic Gates Foundation, uses his privileged, bird’s-eye view to organize what work can be done to avoid the “next pandemic.” Though humanity has moved onto other challenges, doing…
Siddhartha Mukherjee, one of our age’s most brilliant medical writers, is a cancer doctor with research interests in the basic sciences of cell biology and genetics. He is also an engaging writer with a deep knowledge of the history of science. His books, one of which has won a Pulitzer Prize, combine all these crosscurrents to convey a compelling narrative. He’s done it for both genetics and cancer, and here, he hits another home run…
I write this review sixteen years after the publication of this book – a lifetime for rapidly advancing scientific insights. Nonetheless, this book represents an early attempt to understand how to deal with the relationship of HIV infection and severe mental illness (bipolar disorder, schizophrenia, or major depressive disorder). This problem was noted early in HIV’s emergence and began to be systemically addressed more in the 1990s. HIV infection rates at the time of publication…
The discovery of Highly Active Anti-Retroviral Therapy (HAART) in the 1990s was a historical game-changer for those infected with HIV. Instead of dying with AIDS four years after diagnosis, patients infected could now live for decades going forward. While certainly a welcome happening, HAART opened up a new set of questions for those affected with HIV along with healthcare providers: How do we handle growing old with HIV? And how does medicine cope with an…
In our generation, codes comprise some of the most interesting subjects of study. We code computers to do work for us; we also are beginning to decode the genetic code to propel life forward. The discovery of CRISPR promises to allow us to edit the human genome, and Professor Doudna sits among this innovation’s prime discoverers. Along with another female scientist Professor Charpentier, she won the Nobel Prize for Chemistry in 2020. This biography, written…
Today, December 1, is World AIDS Day. During my second year of medical school, I remember sitting in on a full day of presentations about AIDS. Gabriel Virella always organized an intricate set of lectures on World AIDS Day each year. That year, researchers had just failed (again) in a major trial of a vaccine. Along with immunology, we learned about social and cultural issues about HIV, the different medicines used to treat it, and…
Much has changed since HIV/AIDS first started spreading widely in America. Fortunately, we now have better drugs to treat HIV infections. The healthcare system focuses on prevention through PrEP. America is more accepting of homosexuality, though more progress can always be made. Some things remain similar, though. Preventative vaccines are still a hoped-for but not realized dream. The stigma of a diagnosis still exists, but not nearly as badly as it did in the 1980s…
Healthcare matters, almost by definition, are anxiety-ridden events. Few, if any, people go to doctors for mere enjoyment. If added to that anxiety lies further anxiety about who one loves or how one feels comfortable about their own body, the outcome of a medical transaction can be negatively impacted. Negative healthcare outcomes can lead to decreased quality of life or even length of life. Few people would wish for this, even for people who think,…
The CTSA Program at NIH seeks to advance clinical and translational research – that is, quicken the flow of helpful information across the American healthcare system. This program began in 2006 and has been a big hit. By the time this report was compiled in 2013, a new landscape of translational research began to emerge. This report, from a committee of national figures in the research community, seeks to identify what a “CTSA 2.0” might…