In our generation, codes comprise some of the most interesting subjects of study. We code computers to do work for us; we also are beginning to decode the genetic code to propel life forward. The discovery of CRISPR promises to allow us to edit the human genome, and Professor Doudna sits among this innovation’s prime discoverers. Along with another female scientist Professor Charpentier, she won the Nobel Prize for Chemistry in 2020. This biography, written by eminent historian Walter Isaacson, tells her story in a way that clarifies the historical record, explains the core science, and demonstrates that women do really excellent science.
Doudna was inspired as a teenager to become a scientist by reading Watson’s The Double Helix. Like any scientist, she had to persevere along her path, but she eventually earned a PhD from Harvard University en route to a professorship at UC-Berkeley. She found a professional niche in learning everything about RNA. As explained here, through conversations with Charpentier and work by post-doctoral fellows, she eventually developed a way to edit genes.
However, this discovery only invited controversy. The two labs had co-discovered how to do this in bacteria, but could they do this in humans? Other labs began to pursue this question, too, and two groups claim legal priority in this discovery. The courts may decide who will get the money, but the Nobel committee clearly decided that this all-female duo deserved preeminence. Isaacson, a careful writer with a long history of describing innovation, maintains an unbiased tone when dissecting this dilemma.
Ultimately, this book might prove to be the equivalent of The Double Helix for a new generation of scientists, both male and female. It presents Doudna as a noble figure who studies interesting and impactful things. It also presents a host of postdoctoral workers and collaborators who deservedly find their own place in the scientific folklore. Isaacson, though a historian and biographer – not a scientist – never scrimps on the science. He lucidly and accurately describes the biochemical happenings without over-complexifying or over-simplifying.
This book should receive a broad audience among the reading public. As this book repeatedly trumpets, the life sciences are carrying the banner of innovation in the early twenty-first century. Thus, it behooves everyone to learn how to import its insights into our personal lives. Isaacson writes with clarity and vibrancy enough for the general reader, who may not have an advanced scientific education. He also gives readers a taste of how the structure of American science works by providing glimpses into the labs and administrations. Thus, future scientists can learn how science actually works. Many can, have, and will benefit from Isaacson’s explanation of Doudna and company’s labors, and as with CRISPR, benefits will roll in during coming years.
The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race
By Walter Isaacson
Copyright (c) 2021
Simon & Schuster
ISBN13 9781982115869
Page Count: 536
Genre: Biography, Science
www.amazon.com